I have a photo comic and an illustrated comic. While there are a handful of crossover readers, it's pretty clear that each comic has different audiences. Of course, the subject matter is different, too ^.^
In any case, I've only ever received positive feedback regarding the photo comic. You'll always run into potential readers who won't like the look and therefore won't read the comic, but really that goes for anything. For example, I'm not a fan of stick figures, so I tend to not read stick figure comics (xkcd being a notable exception). Some people don't like manga-styled comics. Some people don't like photo comics.
I think you'll run into more people who are anti-photos. My own opinion of photo comics is kind of on the low side for the most part; however, I do feel it's a legitimate medium and worth the look if done correctly ^.^