I'd like to explain a bit the whole DPI issue as I see many people are getting the wrong impression from it. DPI stands for dots per inch. Pretty straightfoward, it tells you that, in a 300 dpi ratio, there will be 300 pixels per inch on the canvas (an 1 inch x 1 inch canvas will have 300x300 pixels). 300dpi is standard for quality printing (mostly, offset, digital offset, etc).
Usually when working on digital files for printing, you will first check with the printer as to what their specifications are, and then make the file. But since we're mainly a web-first format, we need to go with generalizations and hoping that, if in the future we make prints, our files will meet the requirements

Many people draw at 300dpi, 350dpi, 600dpi, others at 900dpi... This just represents how large your original file will be. Let me tell you, if you send a 900dpi A4 file to a printer, they will ask you to resize it :x Why? Because most of the time, printers (and
RIPs) can't handle such large resolutions. In fact, most laser printers will not print upwards 150dpi of resolution (meaning, that a 300dpi A4 file and a 150dpi A4 will have the same look on paper, because the printer will automatically change the resolution to 150dpi to process the file! This is why we need to print proofs beforehand to see how it will turn out).
Ok, back to the main subject. When creating digital originals,
always work upwards 300dpi if you plan to print in the future. When you create these digital originals, pixel size has little meaning. You need to keep an eye on cm/inches (depending what you use). This will tell you the real printing output result, NOT the pixel number.
However! Once you have your comic finished and pretty, you need to tweak it so it's good for screen and web. Step #1 is to downsize the quality to 72dpi. Why, if 300pixels at 300dpi are the same as 300pixels at 72dpi? Because of file size. And the same reason why regular printers don't take 900dpi file size,
the device is not good to display it! Also, your file is gonna have a lot of metadata saved, and that will make the file very heavy, which will make you waste a lot of bandwidth and downloading time. If you're using Adobe Photoshop, use Save for Web. It will remove a lot of this metadata and your filesize will be at least half of the filesize if you just saved as (I've read that Adobe Fireworks has a more enhanced Save for web, but I haven't tested it yet). Also I should mention that it's good if you keep your originals saved as a lossless file such as .PSD or .TIFF. The way JPEG compression works, is that your pixels will be rearranged each time you save, which people call this "losing information" (more noticeable with photography, but it's important to keep this in mind).
CMYK: print in colors. RGB: web display. Grayscale: if you print in only black ink. This is very important!
Sometimes browsers won't display CMYK files so it's important that when you save for web, change it to RGB. Printers will ask you to change your files to CMYK for print, and if you print in black and white, to Grayscale.
Everyone has a different way of doing their art, and that's great. You just need to find the best way to make it work. For Springiette, I make quick sketches on paper of the characters, no layouts. Then I scan those images, and resize and arrange them on my Strip template, then ink on top of that. For my new comic, I plan to either sketch digitally or on paper, then ink on Manga Studio which is sort of a vector hybrid, which means I can export at 600dpi then resize to 300dpi. (I should add, 600dpi is what they use in Manga industry. Because of the way it's printed (one color pass offset, grayscale), the image needs to be clear. In your particular situation, if the inking is done traditionally, I would draw my originals on a piece of paper that will be DOUBLE the size of your printed page (if you want to print at A5, draw in A4, etc). Scan at 300dpi (or 600dpi, depending on your computer/scanner), color. Save originals large. (This way, the original art is large, thus the canvas size will be large, and the printing output will be large. And you'll be able to resize it to whatever size you need! This is much better than just grabbing a small drawing and kicking up the dpi at the moment of scanning. Clearer lines too!) Then copy the file, flatten image, resize to 72dpi and the pixel size you want your page to display on your website. When you are ready to print, grab that file, make sure it's CMYK, resize it to printing size (always keeping in mind bleed lines). Save at whatever resolution and colorspace the printer asks you. Happy files!

I hope this helped a bit :X
(Just for reference, I am an assistant at university in digital graphic design/printing class. So if you have any questions about printing... I'll be happy to help.)